Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 4.087


Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

Gene SymbolEntrez IDGene Name
FOS 2353 v-fos FBJ murine osteosarcoma viral oncogene homolog
FOSB 2354 FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 8061 FOS-like antigen 1
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOSL1chr11_-_654243850.895.2e-06Click!
JUNDchr19_-_18253436-0.486.0e-02Click!
FOSchr14_+_748152330.411.2e-01Click!
FOSBchr19_+_506630890.312.4e-01Click!
JUNBchr19_+_127632950.117.0e-01Click!


Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_19706979 37.224 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr1_+_181422016 23.844 LAMC2
laminin, gamma 2
chr12_+_13240868 22.919 NM_001423
EMP1
epithelial membrane protein 1
chr1_+_181421984 22.681 LAMC2
laminin, gamma 2
chr1_+_221955876 21.509 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr12_+_13240987 20.984 EMP1
epithelial membrane protein 1
chr17_-_36996611 19.912 NM_000526
KRT14
keratin 14
chr1_+_181421796 17.569 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr1_+_151270301 16.419 NM_003125
SPRR1B
small proline-rich protein 1B
chr19_-_43955984 15.458 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr3_-_152517204 15.415 NM_023915
GPR87
G protein-coupled receptor 87
chr12_-_51173238 14.949 NM_005554
KRT6A
keratin 6A
chr18_+_59593591 14.614 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr1_-_94779727 14.243 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr17_-_37022465 13.650 NM_005557
KRT16
keratin 16
chr1_-_207891264 13.453 NM_001017402
LAMB3
laminin, beta 3
chr18_+_59295123 11.637 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr6_+_83129641 11.598 NM_006670
TPBG
trophoblast glycoprotein
chr17_-_37034288 10.748 NM_000422
KRT17
keratin 17
chr2_-_215967442 10.486 FN1
fibronectin 1
chr3_-_150578103 10.393 TM4SF1
transmembrane 4 L six family member 1
chr4_+_169989680 9.953 NM_001166110
PALLD
palladin, cytoskeletal associated protein
chr17_-_36928604 9.914 NM_002275
KRT15
keratin 15
chr3_-_150578207 9.857 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr3_-_150578148 9.846 TM4SF1
transmembrane 4 L six family member 1
chr1_+_27062215 9.565 NM_006142
SFN
stratifin
chr6_-_138470160 9.358 NM_022121
PERP
PERP, TP53 apoptosis effector
chr18_+_59705918 9.274 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr3_-_150578023 8.538 TM4SF1
transmembrane 4 L six family member 1
chr19_-_56215084 8.429 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr11_+_101488380 8.388 NM_001195045
YAP1
Yes-associated protein 1
chr1_-_150276064 8.189 S100A11
S100 calcium binding protein A11
chr11_-_102174032 8.161 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr11_-_102174102 8.157 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr1_-_151804929 8.130 NM_005978
S100A2
S100 calcium binding protein A2
chr11_-_119499188 8.043 TRIM29
tripartite motif containing 29
chr19_+_43971689 7.991 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr11_-_6298284 7.875 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr10_+_17310475 7.805 VIM
vimentin
chr2_-_166359016 7.753 NM_004482
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr7_+_48094750 7.709 NM_181597
UPP1
uridine phosphorylase 1
chr3_+_30622905 7.599 NM_001024847
NM_003242
TGFBR2

transforming growth factor, beta receptor II (70/80kDa)

chr12_-_105057940 7.558 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr11_-_2907169 7.197 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr11_+_35154775 7.117 CD44
CD44 molecule (Indian blood group)
chr3_-_31997738 6.799 OSBPL10
oxysterol binding protein-like 10
chr1_+_151223180 6.794 NM_005987
SPRR1A
small proline-rich protein 1A
chr3_-_31998241 6.737 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr6_+_121798443 6.693 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr16_+_55199978 6.680 NM_005953
MT2A
metallothionein 2A
chr16_+_56219802 6.669 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr7_+_116099648 6.470 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr11_-_117640196 6.453 MPZL2
myelin protein zero-like 2
chr1_+_34993234 6.429 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chr13_-_37070862 6.325 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr1_-_205272619 6.266 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr13_+_77007809 6.177 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr21_-_35343456 6.100 NM_001754
RUNX1
runt-related transcription factor 1
chr10_+_17310263 5.996 NM_003380
VIM
vimentin
chr11_-_117640407 5.973 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chr11_-_8695974 5.930 ST5
suppression of tumorigenicity 5
chr20_+_33223434 5.757 NM_006404
PROCR
protein C receptor, endothelial
chr11_-_117640166 5.738 MPZL2
myelin protein zero-like 2
chr1_-_150276091 5.624 S100A11
S100 calcium binding protein A11
chr21_-_35343500 5.607 RUNX1
runt-related transcription factor 1
chr7_-_107430566 5.454 NM_002291
LAMB1
laminin, beta 1
chr6_-_134538526 5.384 SGK1
serum/glucocorticoid regulated kinase 1
chr11_+_384199 5.377 NM_007183
PKP3
plakophilin 3
chr12_+_76749199 5.360 NM_014903
NAV3
neuron navigator 3
chr19_-_48661563 5.325 NM_014400
LYPD3
LY6/PLAUR domain containing 3
chr1_-_150276114 5.309 NM_005620
S100A11
S100 calcium binding protein A11
chr11_-_65424434 5.221 FOSL1
FOS-like antigen 1
chr1_+_221966849 5.173 CAPN2
calpain 2, (m/II) large subunit
chr1_+_221966835 5.138 CAPN2
calpain 2, (m/II) large subunit
chr17_+_71229110 5.054 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr6_-_134538762 4.899 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr10_+_121400741 4.852 NM_004281
BAG3
BCL2-associated athanogene 3
chr1_+_151147646 4.754 NM_005547
IVL
involucrin
chr1_+_221966684 4.722 NM_001748
CAPN2
calpain 2, (m/II) large subunit
chr6_-_10527772 4.712 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chrX_-_10761729 4.693 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr10_+_121400881 4.669 BAG3
BCL2-associated athanogene 3
chr11_+_35596310 4.613 NM_014344
FJX1
four jointed box 1 (Drosophila)
chrX_+_135079461 4.593 NM_001167819
FHL1
four and a half LIM domains 1
chr17_-_7434113 4.585 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr9_-_109291866 4.512 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr11_-_65424436 4.488 NM_005438
FOSL1
FOS-like antigen 1
chr5_+_140848905 4.434 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr17_+_71229151 4.417 ITGB4
integrin, beta 4
chr21_-_26465005 4.372 NM_000484
NM_001136129
NM_001136130
NM_201413
NM_201414
APP




amyloid beta (A4) precursor protein




chr5_+_52812165 4.361 FST
follistatin
chr11_-_65424385 4.335 FOSL1
FOS-like antigen 1
chr10_+_121401061 4.334 BAG3
BCL2-associated athanogene 3
chr1_+_154351162 4.294 LMNA
lamin A/C
chr1_+_154351200 4.292 LMNA
lamin A/C
chr5_+_52812236 4.205 NM_006350
NM_013409
FST

follistatin

chr11_+_384238 4.139 PKP3
plakophilin 3
chr6_-_112034166 4.042 NM_001164281
NM_147686
TRAF3IP2

TRAF3 interacting protein 2

chr7_-_93357881 4.041 NM_006528
TFPI2
tissue factor pathway inhibitor 2
chr5_-_1935764 4.036 NM_016358
IRX4
iroquois homeobox 4
chr1_+_35019376 3.962 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chr1_+_154351082 3.910 NM_005572
NM_170707
NM_170708
LMNA


lamin A/C


chr15_+_38923470 3.893 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr8_+_32623792 3.888 NM_013959
NRG1
neuregulin 1
chr13_-_109236897 3.881 NM_003749
IRS2
insulin receptor substrate 2
chr18_+_59788242 3.839 NM_001031848
NM_002640
NM_198833
SERPINB8


serpin peptidase inhibitor, clade B (ovalbumin), member 8


chr4_-_115120251 3.814 NM_024590
ARSJ
arylsulfatase family, member J
chr6_-_112033752 3.797 TRAF3IP2
TRAF3 interacting protein 2
chr1_+_148747110 3.683 NM_004425
NM_022664
ECM1

extracellular matrix protein 1

chr20_-_35586366 3.682 NM_001167823
BLCAP
bladder cancer associated protein
chr1_+_148747208 3.658 ECM1
extracellular matrix protein 1
chr17_+_71229191 3.626 ITGB4
integrin, beta 4
chr10_+_121401032 3.624 BAG3
BCL2-associated athanogene 3
chr10_+_121401076 3.584 BAG3
BCL2-associated athanogene 3
chr17_+_21131940 3.515 NM_002756
MAP2K3
mitogen-activated protein kinase kinase 3
chr3_+_101720753 3.497 TMEM45A
transmembrane protein 45A
chr19_-_18912112 3.487 NM_001145722
NM_001145721
HOMER3

homer homolog 3 (Drosophila)

chr1_-_153209625 3.473 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr1_-_150564302 3.432 NM_002016
FLG
filaggrin
chr1_+_185064654 3.426 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr1_-_151788341 3.414 NM_002960
S100A3
S100 calcium binding protein A3
chr12_-_51153788 3.401 NM_173086
KRT6C
keratin 6C
chr9_-_116920232 3.378 NM_002160
TNC
tenascin C
chr15_-_58477407 3.378 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr17_+_77261401 3.368 NM_004712
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr1_+_44171578 3.333 NM_001136215
NM_057090
NM_057091
ARTN


artemin


chr6_+_30964441 3.328 NM_013994
DDR1
discoidin domain receptor tyrosine kinase 1
chr17_+_71892538 3.282 SPHK1
sphingosine kinase 1
chr15_+_38923914 3.225 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr1_-_151296611 3.224 NM_005988
SPRR2A
small proline-rich protein 2A
chr1_+_81544432 3.222 LPHN2
latrophilin 2
chr11_-_33701073 3.219 NM_001127227
CD59
CD59 molecule, complement regulatory protein
chr2_-_85494664 3.210 CAPG
capping protein (actin filament), gelsolin-like
chr17_+_71893014 3.198 SPHK1
sphingosine kinase 1
chr12_-_53099269 3.173 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr10_+_123862430 3.148 TACC2
transforming, acidic coiled-coil containing protein 2
chr17_+_71892781 3.141 NM_001142602
SPHK1
sphingosine kinase 1
chr2_-_85494639 3.114 CAPG
capping protein (actin filament), gelsolin-like
chr1_+_36394338 3.104 NM_018067
MAP7D1
MAP7 domain containing 1
chr21_-_26464915 3.090 APP
amyloid beta (A4) precursor protein
chr17_+_77261440 3.087 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr19_-_56164628 3.058 NM_002774
KLK6
kallikrein-related peptidase 6
chr3_-_124821868 3.023 MYLK
myosin light chain kinase
chr22_-_43986896 3.014 KIAA0930
KIAA0930
chr6_+_107066422 3.010 NM_001624
AIM1
absent in melanoma 1
chr11_+_696103 3.009 NM_022772
EPS8L2
EPS8-like 2
chr2_-_85490984 2.986 CAPG
capping protein (actin filament), gelsolin-like
chr3_+_106568334 2.986 NM_001627
ALCAM
activated leukocyte cell adhesion molecule
chr1_+_150753601 2.937 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr9_+_33785558 2.923 NM_002771
PRSS3
protease, serine, 3
chr18_+_54039818 2.921 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr3_-_48607596 2.921 NM_000094
COL7A1
collagen, type VII, alpha 1
chr20_-_6052056 2.907 NM_017671
FERMT1
fermitin family member 1
chr18_+_3443771 2.892 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr20_-_43410437 2.889 NM_002999
SDC4
syndecan 4
chr5_-_134942867 2.852 NM_004887
CXCL14
chemokine (C-X-C motif) ligand 14
chr18_+_54039779 2.848 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr17_+_77261477 2.802 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr2_-_113310796 2.799 NM_000576
IL1B
interleukin 1, beta
chr12_-_53099203 2.794 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr6_-_84197573 2.775 NM_002395
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr21_-_35181956 2.689 RUNX1
runt-related transcription factor 1
chr3_+_189413414 2.684 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr2_-_85490997 2.681 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr4_+_74825138 2.672 NM_000584
IL8
interleukin 8
chr5_+_36644187 2.650 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr7_+_23252909 2.623 GPNMB
glycoprotein (transmembrane) nmb
chr6_-_84197477 2.575 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr2_-_73170290 2.575 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr21_+_29439768 2.570 C21orf7
chromosome 21 open reading frame 7
chr5_+_140709907 2.561 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr3_-_124822113 2.527 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr11_+_123491313 2.523 NM_001130142
NM_014622
NM_198315
VWA5A


von Willebrand factor A domain containing 5A


chr7_+_23252945 2.499 GPNMB
glycoprotein (transmembrane) nmb
chr8_-_145088679 2.498 NM_201383
PLEC
plectin
chr1_-_151280201 2.480 NM_006945
SPRR2D
small proline-rich protein 2D
chr15_+_38319326 2.473 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr12_-_53099277 2.453 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr1_+_26480134 2.446 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr10_+_102782151 2.444 SFXN3
sideroflexin 3
chr5_+_35892747 2.442 NM_002185
IL7R
interleukin 7 receptor
chr7_+_23252802 2.426 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr19_-_48866111 2.422 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr6_-_84197463 2.414 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr16_+_65525861 2.403 CES2
carboxylesterase 2
chr12_-_8706637 2.402 NM_003480
MFAP5
microfibrillar associated protein 5
chr17_+_77261447 2.383 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr17_-_37196463 2.373 NM_002230
NM_021991
JUP

junction plakoglobin

chr15_-_53996597 2.368 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr20_-_6051562 2.356 FERMT1
fermitin family member 1
chr7_+_23252915 2.353 GPNMB
glycoprotein (transmembrane) nmb
chr10_-_30064600 2.285 NM_003174
SVIL
supervillin
chr21_-_35343448 2.273 RUNX1
runt-related transcription factor 1
chr20_+_44070946 2.268 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr11_-_62070867 2.249 NM_001620
NM_024060
AHNAK

AHNAK nucleoprotein

chrX_+_135079120 2.242 NM_001159704
FHL1
four and a half LIM domains 1
chr6_-_84197370 2.232 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chrX_-_153290697 2.217 NM_006730
DNASE1L1
deoxyribonuclease I-like 1
chr11_+_62405736 2.216 SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr1_-_85816520 2.212 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.85 9.39e-05 GO:0009888 tissue development
2.96 1.48e-04 GO:0008544 epidermis development
1.75 3.50e-04 GO:0009611 response to wounding
1.88 2.19e-03 GO:0042060 wound healing
1.25 2.46e-03 GO:0032501 multicellular organismal process
9.74 2.97e-03 GO:0031581 hemidesmosome assembly
6.26 1.09e-02 GO:0031424 keratinization
1.82 1.37e-02 GO:0050878 regulation of body fluid levels
1.33 2.06e-02 GO:0048731 system development
2.36 2.25e-02 GO:0009617 response to bacterium
2.74 3.14e-02 GO:0032496 response to lipopolysaccharide
1.29 3.30e-02 GO:0007275 multicellular organismal development
1.84 4.08e-02 GO:0007596 blood coagulation
1.84 4.08e-02 GO:0050817 coagulation
1.29 4.29e-02 GO:0048856 anatomical structure development
1.58 4.43e-02 GO:0042127 regulation of cell proliferation
2.61 4.59e-02 GO:0002237 response to molecule of bacterial origin
1.82 4.94e-02 GO:0007599 hemostasis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
8.10 1.04e-04 GO:0001533 cornified envelope
1.54 1.18e-02 GO:0044421 extracellular region part
2.41 1.20e-02 GO:0005911 cell-cell junction
3.37 2.90e-02 GO:0000502 proteasome complex
1.37 2.92e-02 GO:0005576 extracellular region
8.50 3.90e-02 GO:0005838 proteasome regulatory particle
8.50 3.90e-02 GO:0005952 cAMP-dependent protein kinase complex
2.00 4.51e-02 GO:0005578 proteinaceous extracellular matrix

Nothing significant found in function category.