Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 4.087


Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

Gene SymbolEntrez IDGene Name
FOS 2353 v-fos FBJ murine osteosarcoma viral oncogene homolog
FOSB 2354 FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 8061 FOS-like antigen 1
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOSL1chr11_-_654243850.895.2e-06Click!
JUNDchr19_-_18253436-0.486.0e-02Click!
FOSchr14_+_748152330.411.2e-01Click!
FOSBchr19_+_506630890.312.4e-01Click!
JUNBchr19_+_127632950.117.0e-01Click!


Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_19706979 37.224 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr1_+_181422016 23.844 LAMC2
laminin, gamma 2
chr12_+_13240868 22.919 NM_001423
EMP1
epithelial membrane protein 1
chr1_+_181421984 22.681 LAMC2
laminin, gamma 2
chr1_+_221955876 21.509 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr12_+_13240987 20.984 EMP1
epithelial membrane protein 1
chr17_-_36996611 19.912 NM_000526
KRT14
keratin 14
chr1_+_181421796 17.569 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr1_+_151270301 16.419 NM_003125
SPRR1B
small proline-rich protein 1B
chr19_-_43955984 15.458 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr3_-_152517204 15.415 NM_023915
GPR87
G protein-coupled receptor 87
chr12_-_51173238 14.949 NM_005554
KRT6A
keratin 6A
chr18_+_59593591 14.614 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr1_-_94779727 14.243 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr17_-_37022465 13.650 NM_005557
KRT16
keratin 16
chr1_-_207891264 13.453 NM_001017402
LAMB3
laminin, beta 3
chr18_+_59295123 11.637 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr6_+_83129641 11.598 NM_006670
TPBG
trophoblast glycoprotein
chr17_-_37034288 10.748 NM_000422
KRT17
keratin 17
chr2_-_215967442 10.486 FN1
fibronectin 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
9.74 2.97e-03 GO:0031581 hemidesmosome assembly
6.26 1.09e-02 GO:0031424 keratinization
2.96 1.48e-04 GO:0008544 epidermis development
2.74 3.14e-02 GO:0032496 response to lipopolysaccharide
2.61 4.59e-02 GO:0002237 response to molecule of bacterial origin
2.36 2.25e-02 GO:0009617 response to bacterium
1.88 2.19e-03 GO:0042060 wound healing
1.85 9.39e-05 GO:0009888 tissue development
1.84 4.08e-02 GO:0007596 blood coagulation
1.84 4.08e-02 GO:0050817 coagulation
1.82 1.37e-02 GO:0050878 regulation of body fluid levels
1.82 4.94e-02 GO:0007599 hemostasis
1.75 3.50e-04 GO:0009611 response to wounding
1.58 4.43e-02 GO:0042127 regulation of cell proliferation
1.33 2.06e-02 GO:0048731 system development
1.29 3.30e-02 GO:0007275 multicellular organismal development
1.29 4.29e-02 GO:0048856 anatomical structure development
1.25 2.46e-03 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
8.50 3.90e-02 GO:0005838 proteasome regulatory particle
8.50 3.90e-02 GO:0005952 cAMP-dependent protein kinase complex
8.10 1.04e-04 GO:0001533 cornified envelope
3.37 2.90e-02 GO:0000502 proteasome complex
2.41 1.20e-02 GO:0005911 cell-cell junction
2.00 4.51e-02 GO:0005578 proteinaceous extracellular matrix
1.54 1.18e-02 GO:0044421 extracellular region part
1.37 2.92e-02 GO:0005576 extracellular region

Nothing significant found in function category.